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Ubiquitination of Cx43 signals the internalization and autophagy degradation of gap junctions

(Girao Exp Cell Res 2009; Catarino, Biochem J 2011; Bejarano, Mol Biol Cell 2012; Ribeiro-Rodrigues, FASEBJ 2014) 


Heart ischemia leads to degradation of gap junctions, in cardiomyocytes, through autophagy, and impairment of intercellular communication

(Martins-Marques, Biochem J 2015; Martins-Marques, Biochimie 2015; Santos-Almeida, Am J Physiol Heart Circ Physiol 2015)


Cx43 mediates the communication between exosomes and target cells


Ischemia disrupts exosome-mediated communication between cardiomyocytes - endothelial cells and cardiomyocytes – macrophages


Smurf1 mediates the degradation of Cx43 in cardiomyocytes in pulmonary hypertension


CHIP mediates ubiquitination and degradation of HIF1A, through CMA

(Ferreira, Autophagy 2013; Ferreira, Sci Reports 2015)


CASA regulates cytoskeleton remodeling in endothelial cells subject to disturbed flow and cardiomyocytes undergoing hypertrophy


DNAJB4 determines the fate of E-Cadherin

(Simoes-Correia, Hum Mol Genet 2014)


AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions.

(Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girão H. FASEB J. 2014)


Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs.

(Martins-Marques T, Catarino S, Marques C, Matafome P, Ribeiro-Rodrigues T, Pereira P, Girão H. Biochimie. 2015).[


Ischemia-induced autophagy leads to degradation of gap junction protein Connexin43 in cardiomyocytes.

(Martins-Marques T, Catarino S, Zuzarte M, Marques C, Matafome P, Pereira P, Girão H.

Biochem J. 2015). 


Autophagy and Ubiquitination in Cardiovascular Diseases.

(Martins-Marques T, Ribeiro-Rodrigues T, Pereira P, Codogno P, Girao H.


DNA Cell Biol. 2015).